Correcting the Bias of Empirical Frequency Parameter Estimators in Codon Models
نویسندگان
چکیده
منابع مشابه
Correcting the Bias of Empirical Frequency Parameter Estimators in Codon Models
Markov models of codon substitution are powerful inferential tools for studying biological processes such as natural selection and preferences in amino acid substitution. The equilibrium character distributions of these models are almost always estimated using nucleotide frequencies observed in a sequence alignment, primarily as a matter of historical convention. In this note, we demonstrate th...
متن کاملCorrection: Correcting the Bias of Empirical Frequency Parameter Estimators in Codon Models
There are errors in Equation (3). In the description of Equation (3), the equilibrium frequencies PIX are incorrectly defined in terms of pi, where in fact they should be defined in terms of phi. Please see the corrected description of Equation (3) here.
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Background: Little knowledge of synonymous codon usage pattern of pseudorabies virus (PRV) genome, especially the UL31 gene in the process for its evolution is available. Objectives: In the present study, the codon usage bias between PRV UL31 sequence and the UL31-like sequences was identified. Materials and Methods: We used a comprehensive analysi...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2010
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0011230